The severe functional deficits in patients suffering from traumatic peripheral nerve damage underline the necessity of an optimal therapy. The development of microsurgical techniques in the sixties contributed significantly to the progress in nerve repair. Since then, no major clinical innovation has become established. However, with an increased understanding of cellular and molecular mechanisms underlying nerve regeneration, various tubulization concepts have been developed which yield possible alternatives to direct suturing and to autologous nerve grafting in cases of short nerve defects. The vast knowledge gathered in the field of nerve regeneration needs to be further exploited in order to develop alternative therapeutic strategies to nerve autografting, which can result in donor-site defects and often lead to inappropriate results. Considering the encouraging results from preclinical studies, innovative nerve repair strategies are likely to improve the outcome of reconstructive surgical interventions.
EBSCOhost | | Neurotoxic effects of nonylphenol: a review.
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The structural pre-condition for a reinnervation of muscles will be thought of while the focus will be on damaged muscles of the larynx. Characteristics of a matching donor and expected success in reinnervation of atrophical muscles are presented. A series of surgical techniques to reinnervert the muscles of the larynx of man, dog and horse, as found in literature, is chroniced.